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MGF (Mechano Growth Factor) record · updated 7h ago

Muscle & body compHealing & recoveryGrade B · human evidenceResearch use only
All 3 studiesJump to the evidenceCompare
What is MGF (Mechano Growth Factor) used for?

MGF (Mechano Growth Factor) is a locally expressed IGF-1 splice variant studied in preclinical models for muscle satellite cell activation, repair, and recovery from tissue injury.

Primarily researched for · Muscle & body comp

Development stage

where MGF (Mechano Growth Factor) sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 7 registered trials. It describes the research record, not a recommendation.

Identity
NameMGF (Mechano Growth Factor)
Full name—
Sequence—
ClassGH
Research levelLimited Research
Discovered byCurated master list · 2026
Pharmacology
Mechanism—
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence—
Effect profile · 0–5
Muscle & body comp: Healing 4.0, Muscle 5.0, Metabolic 2.0, Neuro 1.0, Sleep 0.0, Immune 3.0, Skin 2.0Healing & recovery — 4.0 / 5Muscle & body comp — 5.0 / 5Metabolic & appetite — 2.0 / 5Neuro & mood — 1.0 / 5Inflammation & immune — 3.0 / 5Skin & aesthetics — 2.0 / 5HealingMuscleMetabolicNeuroSleepImmuneSkin4.05.02.01.00.03.02.0
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o mini over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Jul 27, 2026. How this works →
Research stats
Total studies3
Human / animal / cellular2 / 1 / 0
Highest trial phasePreclinical
Years covered2026
Latest study14d ago
Publication history
20262026
Research funding
10 NIH projects · $3.2M awarded · through FY2013
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

3 rowsOpen in the library →
StudyTypeYearSummary depth
Proteomics and ex vivo plaque culture identify the insulin-like growth factor axis as a potential regulator of matrix remodelling in carotid plaques.
FindingNot reported in abstract.
Human2026Full text read0.80
Transcriptional remodeling of cardiomyocytes and fibroblasts during post-myocardial infarction recovery.
FindingNot reported in abstract.
Animal—Full text read0.70
Single-cell omics uncovers novel pathological mechanisms and therapeutic targets for congenital heart diseases: insights from integrated intercellular communication analysis.
TakeawayThis review highlights the distinct intercellular communication networks in congenital heart disease subtypes, suggesting potential targets for future therapies.
Human—Full text read0.80

Articles mentioning MGF (Mechano Growth Factor)