Peptides DB
Research-centric peptide and protocol reference hub
Study 13 of 16Eloralintide literatureAddictive behaviors reports · Observational2026

Cue-induced inhibitory control in forensic patients with alcohol use disorder: A link to criminal recidivism risk assessed by factor 2 psychopathy.

Weaker inhibitory control in response to alcohol cues is linked to higher psychopathy scores in forensic patients with alcohol use disorder, suggesting a potential cognitive mechanism connecting substance use to criminal behavior.

Read at Addictive behaviors reportsAdd to compare

Where it sits

this study against the rest of the eloralintide corpus
2
Preclinical
12
Observational · this one
0
Open-label
0
Randomised
2
Reviews

Summary and findings

This study examined the relationship between cue-induced inhibitory control and criminal recidivism risk in forensic patients with alcohol use disorder (AUD) and other substance use disorders (SUD). Fifty-one abstinent male forensic patients completed Go/NoGo tasks under alcohol-related and neutral conditions. Weaker inhibitory control in the alcohol-cued condition was associated with higher psychopathy scores.

How much of this paper we could read: full text read (0.80). We had a clear abstract, so the summary below closely tracks the paper. What this means →
β = -0.79, p = .004n=512026

Abstract

The authors’ words, as Addictive behaviors reports supplied them

Cue-reactivity and impaired inhibitory control represent well-established mechanisms contributing to substance use relapse, which, in turn, increases the risk of criminal reoffending in forensic populations whose offending behavior is closely linked to substance use. In Germany, such individuals may be mandated to custodial addiction treatment under Section 64 of the Criminal Code (§ 64 StGB). To date, it remains largely unexplored whether inhibitory control deficits under substance-cue exposure relate more directly to indicators of criminal recidivism risk in forensic addiction populations. The present work addresses this gap by examining the relationship between cue-induced inhibitory control and a validated proxy of reoffending risk. Fifty-one abstinent male forensic patients (24 with alcohol use disorder (AUD), 27 with other substance use disorders (SUD)) undergoing treatment under Section 64 completed two Go/NoGo tasks assessing inhibitory control under alcohol-related and neutral stimulus conditions. Controlling for relevant covariates, inhibitory performance (adjusted d' ) was used to predict scores on Factor 2 of the Psychopathy Checklist: Screening Version (PCL:SV). Among patients with AUD, weaker inhibitory control in the alcohol-cued condition was strongly associated with higher PCL:SV Factor 2 scores (β = -0.79, <i>p</i> = .004), whereas no such association emerged for the neutral condition or for patients with other SUDs. These findings suggest a context-specific link between cue-elicited inhibitory deficits and criminogenic risk in forensic patients with AUD. Cue-related inhibitory impairments may represent a key cognitive mechanism connecting substance use to criminal (re-)engagement. If replicated longitudinally, such measures may inform future approaches to risk assessment and intervention in forensic addiction treatment.

Background

This paper addresses the relationship between cue-reactivity, inhibitory control, and criminal recidivism risk in forensic patients with substance use disorders. Previous research has established that impaired inhibitory control contributes to substance use relapse, which is linked to criminal behavior. Understanding this relationship is crucial for developing effective risk assessment and intervention strategies in forensic addiction treatment.

Methods

The study involved 51 abstinent male forensic patients, with 24 diagnosed with alcohol use disorder (AUD) and 27 with other substance use disorders (SUD). Participants underwent two Go/NoGo tasks to assess inhibitory control under alcohol-related and neutral conditions. The primary outcome measure was the adjusted d' score predicting Factor 2 scores on the Psychopathy Checklist: Screening Version (PCL:SV).

Results

In the alcohol-cued condition, weaker inhibitory control was significantly associated with higher PCL:SV Factor 2 scores (β = -0.79, p = .004). No significant associations were found for the neutral condition or among patients with other SUDs.

Interpretation

The findings suggest a context-specific link between cue-induced inhibitory deficits and criminogenic risk in patients with AUD. While the effect size is statistically significant, the clinical significance remains uncertain due to the small sample size and lack of longitudinal data. The study highlights the need for further research to validate these findings and explore their implications for risk assessment in forensic settings.

Key findings

  • β = -0.79, p = .004 for AUD patients in alcohol-cued condition.
  • No association for neutral condition or patients with other substance use disorders.

Limitations

  • small sample size n=51
  • focus on male forensic patients limits generalizability
  • no longitudinal data reported
  • no control for potential confounding variables

Elsewhere in the Eloralintide corpus

BHealth service delivery and disease management across Ethiopian health care facilities: An evidence-based analysis of tuberculosis program performance and system determinants.Dialogues in health · 2026 · n=112 · Pediatric TB detection was 2.1% vs. WHO's 12%.reviewBClinical Outcomes and Predictors of Adverse Events in Influenza Patients Managed in a Hospital-at-Home Program: A 10-Year Retrospective Study.American journal of medicine open · 2026 · n=270 · 12.4% had ED visits at 30 days, n=270.HumanBYou are doubly excluded: the interplay of cyberostracism and perceived parental phubbing in predicting problematic smartphone use.Addictive behaviors reports · 2026 · n=428 · Not reported in abstract.HumanBThe Dutch-translated Climate and Health Tool for nurses: cross-cultural adaptation and validation.International journal of nursing studies advances · 2026 · n=292 · Not reported in abstract.reviewBWhen violence meets leadership: Leadership climate as a buffer in the link between violence, harmful alcohol use, and burnout among healthcare workers in Sweden.International journal of nursing studies advances · 2026 · n=2446 · b = 0.007, 95% CI [0.001, 0.016]HumanDEloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial.Lancet (London, England) · 2025