Evaluating the therapeutic impact of tirzepatide in people with partial lipodystrophy.
Tirzepatide may lead to significant reductions in body weight and insulin requirements in patients with partial lipodystrophy, but further prospective studies are needed to confirm these results.
Where it sits
this study against the rest of the tirzepatide corpusSummary and findings
This study evaluated the impact of tirzepatide in 40 patients with partial lipodystrophy over a median follow-up of 9.5 months. Significant reductions were observed in body weight, HbA1c, serum triglycerides, and daily insulin requirements. No therapeutic claims are made.
Abstract
<h4>Background</h4>Lipodystrophy syndromes (LD) are a group of rare conditions characterised by the generalised or partial absence and/or dysfunction of adipocytes. Due to the lack of fat storage capacity, excess lipid accumulates in other tissues, leading to severe insulin resistance. At present, effective therapeutic options remain limited, with metreleptin currently the only specific licensed treatment. To this end, we evaluated the therapeutic impact of tirzepatide in people with partial lipodystrophy (PLD).<h4>Methods</h4>This was a single-centre, retrospective, observational study, including all patients with PLD treated with tirzepatide between January 2022 and September 2025.<h4>Results</h4>40 patients with PLD were included (FPLD1 like =26 (65%), FPLD2 =4 (10%), FPLD3 =7 (17.5%), FPLD7=1 (2.5%), APLD=1 (2.5%), Unclassified=1 (2.5%)). 87.5% (n=35) were female with a median age of 47 years (IQR 39 - 59) and a median BMI of 31.5 kg/m2 (IQR 27.3 - 35.5). After a median 9.5 month follow-up (IQR 7 - 11), marked reductions were seen in body weight from 91.0kg (IQR 75.0 - 106.0) to 82.8kg (IQR 69.0 - 93.4; p<0.0001), in HbA1c from 65 mmol/mol (IQR 54.5 - 85) to 52 mmol/mol (IQR 39 - 62; p<0.0001) and in serum triglycerides from 2.80 mmol/L (IQR 1.6 - 3.7) to 1.83 mmol/L (IQR 1.0 - 2.9; P=0.0005). Daily insulin requirements fell from 177.5 IU (IQR 101.3 - 213.8) to 58.0 IU (IQR 0 - 112.5; P=0.0028).<h4>Conclusion</h4>In patients with partial lipodystrophy, tirzepatide use resulted in substantial statistically significant reductions in weight, glycaemic control, serum triglycerides and daily insulin requirement. We recommend further prospective studies to support these findings and to evaluate its impact earlier in the course of the disorder.
Background
Not reported in abstract.
Methods
Not reported in abstract.
Results
Not reported in abstract.
Interpretation
Not reported in abstract.
Limitations
Not reported in abstract.