Study 14 of 35Vasopressin literaturebiorxiv-preprint · Observational2026

Hemodynamic and Regional Oxygenation Effects of Arginine- Vasopressin Following Congenital Heart Surgery

Arginine-vasopressin may increase blood pressure and regional oxygen extraction in children after cardiac surgery, but potential adverse effects on oxygen balance should be considered.

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Where it sits

this study against the rest of the vasopressin corpus

Preclinical

Observational · this one

Open-label

Randomised

Reviews

Summary and findings

This study evaluated the effects of arginine-vasopressin on hemodynamics and regional oxygenation in 49 children following congenital heart surgery. Patients receiving vasopressin (n=23) were compared to those not receiving it (n=26). The results indicated an increase in systolic blood pressure and oxygen extraction in cerebral and renal tissues.

How much of this paper we could read: full text read (0.80). We had a clear abstract, so the summary below closely tracks the paper. What this means →

Vasopressin dose was independently associated with an increase in systolic blood pressure (p<0.01).2026

Abstract

The authors’ words, as biorxiv-preprint supplied them

<title>Abstract</title> <p>Background: Arginine-vasopressin is widely used for treatment of vasodilatory and mixed shock after pediatric cardiac surgery. Although a favorable effect on blood pressure has been documented, data on organ perfusion and tissue oxygen balance remain limited. <h4>Methods:</h4> We prospectively evaluated an observational cohort of 49 children after reparative cardiac surgery. Median age was 8 months (interquartile range 5 to 59 months) and weight 11.0 kg (interquartile range 7.2 to 26.3 kg). Patients who received arginine-vasopressin (n=23) for hypotension were compared with patients of similar surgical complexity who did not (n=26), using regression analysis. <h4>Results:</h4> Vasopressin dose was independently associated with an increase in systolic blood pressure (p<0.01), an increase in cerebral oxygen extraction (p=0.04), and an increase in renal oxygen extraction (p<0.01). No statistical difference was observed between treated and non-treated patients in diastolic blood pressure, blood lactate, or urine output. <h4>Conclusions:</h4> Arginine-vasopressin therapy restores blood pressure in hypotensive children after cardiac surgery but was associated with increased cerebral and renal oxygen extraction, suggesting possible adverse effects on regional oxygen balance.</p>

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