Endometriosis and cardiovascular disease risk: a meta-analysis of cohort studies.
Endometriosis is associated with a statistically significant increased risk of cardiovascular disease, especially coronary artery disease and myocardial infarction, but the clinical implications of these findings require careful consideration.
Where it sits
this study against the rest of the ll-37 corpusSummary and findings
This meta-analysis evaluated the association between endometriosis (EM) and cardiovascular disease (CVD) risk, synthesizing data from 11 cohort studies with a total of 3,100,610 participants. The analysis found that EM was associated with a 22% increased risk of all-cause CVD. Specific risks for myocardial infarction and coronary artery disease were also reported.
Abstract
Objectives This meta-analysis aimed to evaluate the association between endometriosis (EM) and cardiovascular disease (CVD) risk by synthesizing evidence from large-scale cohort studies, with emphasis on subtype-specific risks and geographic disparities. Methods We systematically searched PubMed, Embase, and Cochrane Library for cohort studies published until December 2024. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using random-effects models. Subgroup analyses stratified CVD subtypes (e.g. ischemic heart disease, atrial fibrillation), continents, and country development levels. Heterogeneity and publication bias were assessed via I2 statistics, sensitivity analyses, and Egger's test. Results Eleven cohort studies (n = 3,100,610 participants) were included. EM was associated with a 22% increased risk of all-cause CVD (HR = 1.22; 95% CI: 1.08-1.38; I2 = 94.6%). Subgroup analyses revealed elevated risks for myocardial infarction (HR = 1.29; 95% CI: 1.10-1.50), coronary artery disease (HR = 1.47; 95% CI: 1.29-1.67), and cerebrovascular events (HR = 1.18; 95% CI: 1.12-1.25), but not heart failure. Geographic disparities were significant, with higher CVD risks in Asian (HR = 1.36; 95% CI: 1.25-1.48) and North American cohorts (HR = 1.37; 95% CI: 1.16-1.61) compared to European populations (HR = 0.93; 95% CI: 0.64-1.34). Conclusions EM is independently associated with an elevated risk of CVD, particularly for coronary artery disease and myocardial infarction. These findings underscore the need for targeted cardiovascular monitoring in EM patients, particularly in high-risk populations.
Background
This paper addresses the potential link between endometriosis and cardiovascular disease risk, a topic of interest given the chronic nature of endometriosis and its systemic implications. Prior studies have suggested that women with endometriosis may have an elevated risk of cardiovascular conditions, but the evidence has been inconsistent. This meta-analysis aims to clarify this association by synthesizing data from multiple cohort studies.
Methods
The study design is a meta-analysis of cohort studies, but specific details regarding the population, sample size, dose, duration, and outcome measures are not reported in the abstract. The analysis presumably includes various cohorts with diagnosed endometriosis and assesses cardiovascular disease outcomes.
Results
Not reported in abstract.
Interpretation
Without specific numeric findings or effect sizes reported, it is challenging to compare these results to existing literature or assess clinical significance. The lack of detail regarding confounding factors and study design limits the conclusions that can be drawn about the relationship between endometriosis and cardiovascular disease risk.
Key findings
- Not reported in abstract.
Limitations
- Not reported in abstract.