Peptides DB

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LL-37

Research-centric overview

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### LL-37 Summary LL-37 is a human cathelicidin antimicrobial peptide that plays a crucial role in the innate immune response, exhibiting antimicrobial, immunomodulatory, and wound healing properties. Its diverse functions make it a subject of interest in various fields of biomedical research.

Community effect votes, structured logs, and side-effect summaries.
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Research log summary heatmap

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No community research logs yet. When structured logs are added, this panel will summarize typical shifts in pain, sleep, and performance.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jun 2, 2026
4
Studies indexed
0
Human
0
Animal
4
AI analyzed
Evidence mix0% human · 0% animal · 0% cellular · 0% review
Highest phase: Preclinical onlyYears covered:
Librarian pulse — latest actionsFull changelog ↓
  • Jun 2, 6:00 AMRefreshedRefreshed content for LL-37
  • May 28, 6:01 AMRefreshedRefreshed content for LL-37
  • May 27, 6:07 AMRefreshedRefreshed content for LL-37

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

Association of Markers of Physical Fitness in the Prevalence and Severity of Periodontal Disease and Its ManagementClinical TrialClinicalTrials.govPublished Nov 3, 2021Added May 27, 2026

This study investigates the association between markers of physical fitness and the prevalence and severity of periodontal disease. The population studied and specific doses of LL-37 were not reported in the abstract. The findings indicate a relationship but do not specify treatment outcomes.

Status: COMPLETED
Studio Clinico Randomizzato Per Valutare l'Efficacia Del Bifidobacterium BB-12® Nel Trattamento Delle Coliche InfantiliClinical TrialClinicalTrials.govPublished Nov 11, 2016Added May 27, 2026

Not reported in abstract.

Phase: NAStatus: COMPLETED
A Multicenter, Randomized, Double-blind, Placebo-controlled Evaluation of Rosacea-related Inflammatory Biochemical Markers in the Skin of Adults With Papulopustular Rosacea Treated With Daily Doxycycline 40 mg (30 mg Immediate Release / 10 mg Delayed Release Beads) CapsulesClinical TrialClinicalTrials.govPublished Apr 1, 2011Added May 27, 2026

This study evaluated the effects of daily doxycycline 40 mg on inflammatory biochemical markers in adults with papulopustular rosacea. The study involved a multicenter, randomized, double-blind, placebo-controlled design. The specific outcomes related to LL-37 were not detailed in the abstract.

Phase: PHASE4Status: COMPLETED
A Study on the Safety and Effectiveness of Bifidobacterium Longum Subsp. infantisBI45 in Improving Intestinal and Immune FunctionsClinical TrialClinicalTrials.govPublished Mar 15, 2025Added May 27, 2026

Not reported in abstract.

Phase: NAStatus: NOT_YET_RECRUITING
Clinical Trial of Oral Phenylbutyrate and Vitamin D Adjunctive Therapy in Pulmonary Tuberculosis in Bangladesh: a Pilot StudyClinical TrialClinicalTrials.govPublished Dec 1, 2010Added May 27, 2026

This pilot study evaluated the effects of oral phenylbutyrate and vitamin D as adjunctive therapy in patients with pulmonary tuberculosis in Bangladesh. The specific outcomes measured were not detailed in the abstract. The study aimed to explore potential benefits of these adjunctive treatments in the context of tuberculosis management.

Phase: PHASE2Status: COMPLETED
A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg UlcersClinical TrialClinicalTrials.govPublished Jul 1, 2014Added Apr 16, 2026

This study evaluated the pharmacodynamic effects of HP802-247 in patients with venous leg ulcers. The study involved an unspecified dose and duration, focusing on the healing of ulcers. No therapeutic claims are made regarding the outcomes.

Phase: PHASE2Status: TERMINATED
Integrated Extreme Trait Analysis to Understand the Etiology of Eczema Herpeticum (ADRN-06)Clinical TrialClinicalTrials.govPublished Feb 22, 2017Added Apr 16, 2026

This study aimed to understand the etiology of eczema herpeticum through integrated extreme trait analysis. The specific peptide LL-37 was investigated, although details on dosage and population are not provided. The findings regarding the relationship between LL-37 and eczema herpeticum are not reported in the abstract.

Status: COMPLETED
Effect of High-Dose Vitamin D3 on Alveolar Macrophage Function, LL-37, and Oxidative Stress in Smokers and Non-Smokers With and Without HIVClinical TrialClinicalTrials.govPublished Apr 11, 2018Added Apr 16, 2026

This study evaluated the effect of high-dose Vitamin D3 on alveolar macrophage function, LL-37 levels, and oxidative stress in smokers and non-smokers with and without HIV. The specific dose and duration were not reported in the abstract. The findings related to LL-37 and oxidative stress were not detailed.

Phase: PHASE1Status: TERMINATED
"Salivary Levels of Cathelicidin LL-37 in Patients With Oral Potentially Malignant Lesions, A Case Control Study"Clinical TrialClinicalTrials.govPublished Jul 1, 2023Added Apr 16, 2026

This study measured salivary levels of cathelicidin LL-37 in patients with oral potentially malignant lesions compared to a control group. The findings aim to explore the association between LL-37 levels and oral lesions. No therapeutic claims are made.

Status: COMPLETED
A Study on the Safety and Effectiveness of Limosilactobacillus Fermentum LF61 in Improving Intestinal and Immune FunctionsClinical TrialClinicalTrials.govPublished Mar 10, 2025Added Apr 16, 2026

Not reported in abstract.

Phase: NAStatus: NOT_YET_RECRUITING
Semantic Scholar search for LL-37StudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

LL-37-biofunctionalized titanium improves soft tissue seal surrounding the dental implant from the perspective of optimizing a race to the surface.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Structural and mechanistic divergence in LL-37, HNP-1, and Magainin-2: An integrated computational and biophysical analysis.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

External databases

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Community research logs (detail)

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Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

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Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

11h agoRefreshai-researcher85%

Refreshed content for LL-37

5d agoRefreshai-researcher85%

Refreshed content for LL-37

6d agoRefreshai-researcher85%

Refreshed content for LL-37

May 26task_runlibrarian-runner

Completed task: Refresh content for LL-37

May 26Refreshdiscovery50%

Refreshed content for LL-37

May 26SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for LL-37..."