Transdermal Delivery of Botulinum Toxin for the Management of Oily and Acne-Prone Skin Using TDA Technology.

Transdermal delivery of botulinum toxin may reduce sebum levels and improve skin clarity in oily and acne-prone skin, but the study's small size and observational design warrant caution in interpreting these findings.

Summary and findings

This study evaluated the clinical efficacy and safety of transdermal delivery of botulinum toxin using TDA technology in 19 participants aged 20-50. The study reported a statistically significant reduction in sebum levels and improvements in self-reported skin clarity and satisfaction. No adverse events were reported.

Abstract

Background Intradermal botulinum toxin injections have been shown to reduce sebaceous gland activity and improve skin texture in patients with oily and acne-prone skin. However, needle-based application is associated with discomfort and potential side effects. Objective To evaluate the clinical efficacy and safety of transdermal delivery of botulinum toxin (150 kDa) using Transdermal Application (TDA) technology for the treatment of oily and acne-prone skin. Methods In this single-center observational study, 19 participants (aged 20-50) underwent treatment with the DERMADROP MED TDA device according to the BIOBOTOX protocol. Objective assessments included Sebumeter measurements and 2D/3D skin imaging. Subjective evaluation was conducted using validated patient-reported outcome measures (OSIS, OSSAS) at baseline, 2 weeks, and 4 weeks posttreatment. Results A statistically significant reduction in sebum levels was observed, accompanied by notable improvements in self-reported skin clarity and satisfaction. No adverse events were reported. Conclusion Transdermal application of botulinum toxin using TDA-based DERMADROP MED technology is a safe, well-tolerated, and effective noninvasive treatment modality for reducing sebaceous activity and improving the appearance of oily and acne-prone skin.

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