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IGF-1 LR3 (Long R3 IGF-1) record · updated 20h ago

Muscle & body compMetabolic & appetiteGrade B · human evidenceResearch use only
All 9 studiesJump to the evidenceCompare
What is IGF-1 LR3 (Long R3 IGF-1) used for?

IGF-1 LR3 is a long-acting synthetic IGF-1 analog with reduced binding-protein affinity, used as a research-grade IGF-1 receptor agonist studied for muscle and tissue growth.

How it works: IGF-1 receptor agonist

Primarily researched for · Muscle & body comp

Development stage

where IGF-1 LR3 (Long R3 IGF-1) sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 40 registered trials. It describes the research record, not a recommendation.

Identity
NameIGF-1 LR3 (Long R3 IGF-1)
Chain length—
Molecular weight—
Formula—
Structure type—
ClassMuscle
Research levelPreclinical
Discovered byCurated master list · 2026
Pharmacology
MechanismIGF-1 receptor agonist
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.80
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Aug 15, 2026. How this works →
Research stats
Total studies9
Human / animal / cellular2 / 3 / 3
Highest trial phasePreclinical
Years covered2014–2026
Latest study10d ago
Publication history
20142026
Research funding
—no NIH grants found
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

9 rowsOpen in the library →
StudyTypeYearSummary depth
Long-term effectiveness of typhoid conjugate vaccine in Nepal.
TakeawayNot reported in abstract.
—2026Title only0.10
Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis.
Finding30% increase in glomerular filtration rate (GFR).
Animal2026Full text read0.70
Long-Term Survival Advantage of Reoperative Surgical Mitral Valve Replacement Over Transcatheter Mitral Valve-in-Valve: A Multicenter Cohort.
Finding20.3% mortality for rSMVR vs 40.9% for mViV at 5 years, P = .01
Human2026Full text read0.80
Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.
Finding0.5 g/L XynCDBFV-IGF-1 and 1 g/L XynCDBFV-LR3 IGF-1 achieved in a 15-L bioreactor.
In vitro2023Full text read0.70
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
FindingNot reported in abstract.
Animal2025Full text read0.70
Zein-Derived Peptides from Corn Promote the Proliferation of C<sub>2</sub>C<sub>12</sub> Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways.
FindingCell viability increased by 33.37 to 42.39% with zein peptides at 0.05-0.2 mg/mL.
In vitro2024Full text read0.70
Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy.
FindingNot reported in abstract.
In vitro2024Full text read0.70
Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice.
FindingNot reported in abstract.
Animal2014Full text read0.70
LRP4 and Agrin Are Modulated by Cartilage Degeneration and Involved in β-Catenin Signaling in Human Articular Chondrocytes.
FindingNot reported in abstract.
Human2025Full text read0.70

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching IGF-1 LR3 (Long R3 IGF-1) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much IGF-1 LR3 (Long R3 IGF-1) is discussed should be drawn from it.