Peptides DB
Research-centric peptide and protocol reference hub

Hexarelin record · updated 6h ago

Muscle & body compMetabolic & appetiteGrade B · human evidenceResearch use only
All 8 studiesJump to the evidenceCompare
What is Hexarelin used for?

Hexarelin is a synthetic hexapeptide that belongs to the growth hormone secretagogue (GHS) class, known for its ability to stimulate growth hormone release from the pituitary gland. It has been investigated for its potential therapeutic applications in various conditions, including muscle wasting and age-related decline in growth hormone levels.

How it works: GHS-R agonist

Primarily researched for · Muscle & body compRoute · Subcutaneous injection

Development stage

where Hexarelin sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 7 registered trials. It describes the research record, not a recommendation.

Identity
NameHexarelin
Chain length—
Molecular weight887 Da
FormulaC47H58N12O6
Structure typeNot established
ClassGH
Research levelWell Studied
Discovered byAdded before provenance tracking · 2025

Mass and formula from PubChem CID 6918297. No verified residue count for this compound.

Pharmacology
MechanismGHS-R agonist
RouteSubcutaneous injection
Half-life~2.5 hours
Time to peak30 min
Duration~6 hours
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Jul 28, 2026. How this works →
Research stats
Total studies8
Human / animal / cellular1 / 5 / 1
Highest trial phasePreclinical
Years covered2010–2026
Latest study2mo ago
Publication history
20102026
Research funding
8 NIH projects · $2.6M awarded · through FY2010
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports2
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

8 rowsOpen in the library →
StudyTypeYearSummary depth
GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats.
FindingNot reported in abstract.
Animal2026Partial text0.50
Hexarelin promotes the survival of retinal ganglion cells after optic nerve transection.
FindingSurvival rates of RGC in saline, 25 μg/kg, 50 μg/kg, and 100 μg/kg hexarelin-treated hamsters were 51.2%, 62.4%, 68.5%, and 74.6%, respectively, in 7 days ONT.
Animal2026Full text read0.70
Growth Hormone-Releasing Peptide-6 (GHRP-6) Ameliorates Post-Infarct Ventricular Remodeling and Systolic Dysfunction in a Model of Permanent Coronary Ligation.
FindingNot reported in abstract.
Animal2026Full text read0.70
Investigating the impact of COVID-19 on performance and image enhancing drug use
Finding45% reported a change in PIED use during lockdown, n=27.
Human2021Full text read0.80
Hexarelin promotes the survival of retinal ganglion cells after optic nerve transection.
FindingSurvival rates of RGCs were 74.6% at 100 μg/kg hexarelin after 7 days ONT.
Animal2026Full text read0.70
Semantic Scholar search for Hexarelin
TakeawayNot reported in abstract.
—2010Title only0.00
Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts.
FindingNot reported in abstract.
In vitro2023Partial text0.60
Pharmacological targeting of the hyper-inflammatory response to SARS-CoV-2-infected K18-hACE2 mice using a cluster of differentiation 36 receptor modulator.
TakeawayNot reported in abstract.
Animal2024Title only0.20

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Hexarelin will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Hexarelin is discussed should be drawn from it.

Articles mentioning Hexarelin