Research library

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Survodutide at doses of 3.6 mg and 6.0 mg resulted in significant weight loss in adults with obesity and type 2 diabetes compared to placebo over 76 weeks.

-8.2% weight change in the 3.6-mg group at week 76, n=250, 95% CI -9.2 to -7.2.

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A

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Survodutide showed an 18.7% body-weight reduction at 46 weeks in a phase 2 trial, but long-term safety and effectiveness are still uncertain.

18.7% body-weight reduction at 46 weeks.

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C

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Survodutide showed improvements in metabolic and renal outcomes in a mouse model of diabetic kidney disease, but its relevance to human treatment remains unclear.

Not reported in abstract.

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A

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Survodutide at doses of 3.6 mg and 6.0 mg weekly resulted in significant weight loss compared to placebo in adults with obesity and type 2 diabetes, but gastrointestinal side effects were common.

-8.2% weight change in the 3.6-mg group at week 76, n=250, 95% CI -9.2 to -7.2

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A

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In adults with obesity and at-risk MASLD, survodutide treatment resulted in significant reductions in liver fat and body weight compared to placebo.

84.2% of survodutide-treated patients versus 24.3% of placebo-treated patients had ≥30% reduction in LFC, P<0.0001.

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A

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Survodutide resulted in significant weight loss in adults with obesity without diabetes compared to placebo, but the clinical relevance of the findings should be considered cautiously.

-12.2% mean change in body weight from baseline in the 3.6-mg group at week 76, 95% CI -13.6 to -10.8.

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D

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Not reported in abstract.

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D

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Lactiplantibacillus plantarum shows promise as a probiotic for IBD, but further research is needed to translate these findings into clinical practice.

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C

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The study reveals a hydrogen shuttle mechanism that significantly increases defect generation in UV-grade fused quartz, offering insights into material stability for optical applications.

20-fold increase in Ge-E' generation rate in subsequent UV cycles.

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B

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Conventional clips used for perforation closure in ESD can cause strangulated ileus, necessitating careful post-procedure monitoring.

Not reported in abstract.

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C

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The study presents engineered micro-scaffolds that may improve bone graft performance by enhancing stability and nutrient delivery, but further research is needed to confirm clinical relevance.

mean BV/TV values of 9.05-12.74% at 12 weeks

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C

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The study suggests that targeting ABCA1 palmitoylation may help improve bone regeneration in aged cells, but further research is needed to confirm these findings in humans.

Not reported in abstract.

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D

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Survodutide shows promise for significant weight loss and glycemic control, but higher discontinuation rates due to side effects raise concerns about its long-term use.

Weight loss up to 18.7% in Phase 2 trials.

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A

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Not reported in abstract.

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D

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Not reported in abstract.

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B

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In larger patients, central liver measurements may be preferred over peripheral measurements when evaluating diffuse liver attenuation using dual-layer CT.

Median absolute whole-liver TNC-VNC differences were 4.4 HU in the portal venous phase.

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A

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Keverprazan-amoxicillin therapy is non-inferior to esomeprazole-amoxicillin therapy for H. pylori eradication, but the differences in efficacy are not statistically significant.

Eradication rate for KA group was 87.9% vs 80.3% for EA group in ITT analysis, p=0.092.

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B

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Piper regnellii infusion shows significant effects on reducing inflammatory mediators and calcium oxalate crystals, but further research is needed to confirm its clinical relevance.

90.4% reduction in calcium oxalate crystals at 1.5 mg/mL.

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C

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C. spinosa shows potential for reducing diarrheal episodes and fluid accumulation in animal models, supporting its traditional use for gastrointestinal issues.

C. spinosa (50-200 mg/kg) significantly (p < 0.05) lessened diarrheal episodes.

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D

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This consensus statement highlights the importance of addressing nutritional and psychological needs for patients on incretin-based therapies, but specific outcomes or evidence to support the recommendations are not provided.

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B

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Not reported in abstract.

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A

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Not reported in abstract.

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B

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This study maps the translational landscape of keratinocytes during fungal infection, revealing extensive regulatory mechanisms that could inform future research.

3,189 differentially expressed genes.

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B

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Healthcare workers in Malawi and Zimbabwe face significant barriers in providing bereavement support, including feelings of inadequacy and lack of organizational support.

Not reported in abstract.

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D

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By 2026, 45.9% of Medicare Part D plans provided biosimilar-exclusive coverage for adalimumab, with median specialty-tier coinsurance at 25% for these plans.

In 2026, median specialty-tier coinsurance was 25% among biosimilar-only plans.

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