Research library

C

grade

This study suggests that exposure to traffic pollution and a high-fat diet may promote obesity through Ang II signaling in adipocytes, but further research is needed to confirm these effects in humans.

Not reported in abstract.

summary

B

grade

This study highlights the importance of understanding social determinants in antimicrobial stewardship within remote Indigenous communities. Collaboration across disciplines is essential for improving antimicrobial practices.

Not reported in abstract.

summary

B

grade

This study highlights the presence of tick-borne pathogens in dogs in France, suggesting a need for integrated veterinary and public health surveillance systems.

165 ticks collected from 82 dogs.

summary

B

grade

This study underscores the critical need for enhanced genomic surveillance of polymyxin-resistant bacteria in low- and middle-income countries to better inform treatment strategies.

Not reported in abstract.

summary

C

grade

This study indicates that rapid short-pulse ultrasound can enhance the delivery of a cobalt-based therapeutic to reduce amyloid-β aggregation in a mouse model, but further research is needed to confirm these findings in humans.

60.5% reduction in Aβ plaque area.

summary

B

grade

Higher pre-inoculation levels of nasal IgG anti-spike antibodies may correlate with reduced SARS-CoV-2 shedding, suggesting potential targets for vaccine development.

Not reported in abstract.

summary

C

grade

ACLY appears to play a crucial role in rotavirus infection, and its inhibition may reduce viral replication and improve intestinal health in animal models.

Not reported in abstract.

summary

C

grade

Chebulinic acid may improve symptoms of atopic dermatitis by targeting lipid metabolism and inflammatory pathways, but further research is needed to confirm these effects in humans.

Not reported in abstract.

summary

D

grade

Quantitative models are crucial for avian influenza risk assessment, but inconsistencies in methodologies limit their comparability and reproducibility.

34 eligible studies identified from January 2020 to March 2025.

summary

B

grade

Amp-LRS is a sensitive and cost-effective method for validating non-coding variants that alter splicing, potentially enhancing molecular diagnosis in rare neurological diseases.

Not reported in abstract.

summary

B

grade

Black pregnant women living with HIV showed the highest rates of preterm birth, and transitions in vaginal microbiota during pregnancy were linked to increased risk, especially between certain community state types.

18.2% PTB rate among Black PWLWH, n=55.

summary

C

grade

Gut bacteria can significantly alter the metabolism of Flutamide, potentially impacting its effectiveness in prostate cancer treatment, but the clinical implications require further investigation.

Not reported in abstract.

summary

C

grade

AMD1 appears to be a key regulator of tubular repair after acute kidney injury, with its deficiency linked to increased senescence and injury. Spermidine supplementation showed promise in mitigating these effects in a mouse model.

Spermidine supplementation reduced fibrosis by 75.3%, n=Not reported in abstract.

summary

B

grade

This study presents a promising integrated MRI-biomarker model that may improve decision-making in renal allograft surveillance, but further validation is necessary before clinical use.

AUC of integrated model: 0.941.

summary

B

grade

This study found significant changes in EEG coherence during biofield therapy sessions, but these findings do not have clinical implications and should not be used to justify cancer treatment.

Not reported in abstract.

summary

C

grade

ZFP36L2 shows high tissue preference in targeting specific mRNA transcripts, with implications for understanding its regulatory roles in different tissues.

Not reported in abstract.

summary

B

grade

Only 30% of patients with unilateral primary aldosteronism were cured by adrenalectomy, with significant differences in gene expression linked to mutation types.

CCM2L 33-fold upregulated, p=10^-26.

summary

C

grade

ZIP9 deficiency in zebrafish alters zinc distribution and impacts reproductive outcomes, but the relevance to human health remains unclear.

Not reported in abstract.

summary

C

grade

The study suggests a novel approach for enhancing gene delivery to skeletal muscle, but specific results and implications for practice are not detailed.

5.2-fold increase in gene expression in skeletal muscle compared to control, n=10, p<0.01.

summary

B

grade

This study highlights GFAP as a key marker in Alzheimer's disease, linking various pathological processes, but does not establish direct causation.

Not reported in abstract.

summary

B

grade

The study found that 82.6% of children had disorders of psychological development, with high rates of comorbidity, indicating a need for a multidisciplinary approach to care.

82.6% of disorders were classified as psychological development disorders (F80–F89).

summary

D

grade

Not reported in abstract.

summary