A
grade
Preclinical and First-In-Human Evaluation of Ribupatide (HRS9531), a Dual GLP-1/GIP Receptor Agonist.
Ribupatide · Diabetes, obesity & metabolism · 2023 · RCT · Phase 1 · n=90High-impact journal
Ribupatide showed a favorable safety profile and significant weight loss in a small Phase 1 trial, but further studies are needed to confirm these effects in larger populations.
Mean weight change in ribupatide groups ranged from -4.3 kg (-6.7%) to -7.7 kg (-9.6%), compared with -1.2 kg (-1.4%) in the placebo group.