D
grade
An NAD(+)-responsive adipose signal coordinates inter-organ defense against muscle atrophy.
NAD+ (Nicotinamide Adenine Dinucleotide) · Cell metabolism · 2026Top journal
Not reported in abstract.
Research library
Every indexed study on every peptide in the database, with a machine summary and the numbers that matter pulled out. Filter on the left; the register updates as you go.
2423studies indexed1086with human data145registered trials2091carry a numeric findingLibrarian added 2 studies today
Showing 41 studiesSortNewest indexed ▾
B
grade
Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial.
NAD+ (Nicotinamide Adenine Dinucleotide) · JAMA · 2026Top journal
Not reported in abstract.
C
grade
Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health.
NAD+ (Nicotinamide Adenine Dinucleotide) · Cell metabolism · 2026 · ObservationalTop journal
ACC1 is critical for the maintenance and function of adipose ILC2s, and its deficiency can lead to metabolic issues in obesity. Supplementation with nicotinamide riboside may help restore ILC2 function.
Not reported in abstract.
C
grade
Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
NAD+ (Nicotinamide Adenine Dinucleotide) · biorxiv-preprint · 2023 · Observational
Long-term NMN treatment increased median lifespan by 8.5% in female mice, with varying effects on healthspan and metabolic health in males.
8.5% increase in median lifespan in female mice.
C
grade
The mitochondrial deacetylase SIRT3 is nonessential for cyclophilin D-dependent procoagulant platelet formation in mice.
NAD+ (Nicotinamide Adenine Dinucleotide) · Platelets · 2026 · Observational
SIRT3 is not required for procoagulant platelet formation, indicating that platelets may rely on different mechanisms for activation.
Not reported in abstract.
D
grade
A comprehensive review of small molecule drugs approved by the FDA in 2025: advance and prospect.
NAD+ (Nicotinamide Adenine Dinucleotide) · Journal of enzyme inhibition and medicinal chemistry · 2026 · Review
Small molecule drugs remain crucial in drug discovery, with advancements in design technologies driving their development. The review offers insights but lacks clinical outcome data.
31 of 46 FDA-approved drugs in 2025 were small molecule drugs.
C
grade
Nicotinamide-derived tumor-targeting carbon dots for Cancer Photothermal therapy.
NAD+ (Nicotinamide Adenine Dinucleotide) · Journal of colloid and interface science · 2026 · Animal study · Preclinical
NAM-derived carbon dots show promise for targeted cancer photothermal therapy by exploiting Ki67 affinity, achieving complete tumor regression in preclinical models.
Binding energy of NAM-CDs to Ki67 was -7.7 kcal/mol.
C
grade
Mitochondrial-targeted nano-enhancer driving a self-amplifying NAD<sup>+</sup> feedback loop to reprogram MSC spheroids metabolism for accelerated bone regeneration.
NAD+ (Nicotinamide Adenine Dinucleotide) · Biomaterials · 2026 · Animal study · Preclinical
A mitochondria-targeted nano-enhancer can shift MSC metabolism to improve bone regeneration in rats, but human applicability is uncertain.
D
grade
Pyridoxal photoenzymes for asymmetric radical-radical cross-couplings.
NAD+ (Nicotinamide Adenine Dinucleotide) · Nature · 2026Top journal
Not reported in abstract.
C
grade
Phage anti-defense genes targeting NAD<sup>+</sup> metabolism and DNA replication are associated with a broad host range against <i>Klebsiella pneumoniae</i>.
NAD+ (Nicotinamide Adenine Dinucleotide) · Virulence · 2026 · Observational · Preclinical
The study identifies key genetic factors that could help engineer phages with a broader host range against Klebsiella pneumoniae, but further research is needed to confirm these findings in humans.
Not reported in abstract.
C
grade
Mitogenomic characterisation of non-native freshwater snails in Australia: Implications for biosecurity and trematode vector surveillance.
NAD+ (Nicotinamide Adenine Dinucleotide) · One health (Amsterdam, Netherlands) · 2026 · Animal study
This genomic study enhances biosecurity preparedness by providing molecular tools for monitoring non-native snail species in Australia.
Genome sizes ranged from 13.7 to 14.3 kb.
D
grade
Unlocking the healing power of Berberine: A promising aid for multiple sclerosis.
NAD+ (Nicotinamide Adenine Dinucleotide) · IBRO neuroscience reports · 2026 · Review
Berberine shows promise in preclinical MS models, but clinical trials are necessary to confirm its efficacy and safety in humans.
Not reported in abstract.
D
grade
Efficacy of tannins as silage additives to inhibit deamination process during ensiling: a meta-analysis and <i>in silico</i> approach.
NAD+ (Nicotinamide Adenine Dinucleotide) · Veterinary and animal science · 2026 · Meta-analysis
Tannins show promise in reducing protein degradation during ensiling, but further experimental validation is needed to confirm their practical benefits.
Tannin supplementation significantly reduced NH₃-N, NPN, and soluble nitrogen concentrations (p < 0.001).
C
grade
Evaluation of the safety and potential genotoxicity of a high-purity mogroside ingredient containing siamenoside I produced from a modified strain of <i>Yarrowia lipolytica</i>.
NAD+ (Nicotinamide Adenine Dinucleotide) · Toxicology reports · 2026 · Animal study · Preclinical
The high-purity mogroside ingredient appears safe in rats, with no genotoxic effects observed at high doses. Human studies are needed for confirmation.
NOAEL of 50,000 ppm in male rats (3309 mg/kg-bw/day) and female rats (3362 mg/kg-bw/day) in 90-day study.
C
grade
Evolution of alcohol oxidase for improved methanol bioconversion and formaldehyde tolerance.
NAD+ (Nicotinamide Adenine Dinucleotide) · Synthetic and systems biotechnology · 2026 · In vitro
Directed evolution of GtAOX_M3 significantly enhances methanol bioconversion efficiency, offering potential industrial applications.
Sixfold increase in catalytic efficiency (7.7 s^-1 mM^-1).
C
grade
Improved catalytic efficiency of P450 OleP for converting lithocholic acid into murideoxycholic and ursodeoxycholic acids through semi-rational and rational design.
NAD+ (Nicotinamide Adenine Dinucleotide) · Synthetic and systems biotechnology · 2026 · In vitro · Preclinical
Engineered P450 OleP mutants show enhanced catalytic efficiency for synthesizing therapeutic bile acids from lithocholic acid, but further research is needed to assess industrial applicability.
MDCA conversion rate improved from 32.5% to 98.3% with S240A mutant.
C
grade
Complete POR ablation in human adrenal cells reveals steroidogenic rerouting and variant-dependent loss of cytochrome P450 support
NAD+ (Nicotinamide Adenine Dinucleotide) · biorxiv-preprint · 2026 · Animal study
This study provides a novel approach to understanding the effects of POR mutations on steroid hormone synthesis using engineered human cell models.
Not reported in abstract.
D
grade
Transancestral TWAS Enrichment of NMN- Informed Pathways in Type 2 Diabetes: CPT2- Linked Fatty-Acid Oxidation and MAP2K1/MAPK3 Drivers as Translational Bridges
NAD+ (Nicotinamide Adenine Dinucleotide) · biorxiv-preprint · 2026 · Observational
This study highlights significant genetic associations between NAD+ precursors and type 2 diabetes across different ancestry groups, particularly noting a strong signal in the European population.
Stouffer Z = −9.70 for fatty-acid-degradation association in the European group, permutation p = 0.0077.
D
grade
Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD(+) to eradicate KRAS-driven AML.
NAD+ (Nicotinamide Adenine Dinucleotide) · Cell metabolism · 2026Top journal
Not reported in abstract.
D
grade
NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis.
NAD+ (Nicotinamide Adenine Dinucleotide) · Cell metabolism · 2026Top journal
Not reported in abstract.
B
grade
Metabolite-specific Reproducibility of Cerebral <sup>31</sup> P-MRS at 3T: Recommendations for Clinical Research
NAD+ (Nicotinamide Adenine Dinucleotide) · biorxiv-preprint · 2026 · Observational
This study highlights the variability in 31P-MRS measurements of brain metabolites, emphasizing the need for careful planning in clinical trials to ensure reliable results.
Test-retest variability ranged from ∼5-25 CoV%, n=Not reported in abstract.
C
grade
Aging disrupts cumulus-oocyte NAD homeostasis
NAD+ (Nicotinamide Adenine Dinucleotide) · biorxiv-preprint · 2023 · Observational · Preclinical · n=30
Aging appears to disrupt the metabolic coupling between oocytes and cumulus cells, which may impair NAD homeostasis and contribute to reproductive challenges.
Not reported in abstract.
C
grade
The placental metabolic clock.
NAD+ (Nicotinamide Adenine Dinucleotide) · Science (New York, N.Y.) · 2026Top journal
NAD+ depletion appears to trigger a countdown to birth in mice, but the implications for human pregnancy remain unclear.
D
grade
Mitochondrial quality control in human ageing and longevity.
NAD+ (Nicotinamide Adenine Dinucleotide) · Nature metabolism · 2026 · ReviewTop journal
Mitochondrial quality control is vital for healthy ageing, and strategies like NAD+ may support this process, though specific evidence is not detailed in the review.
C
grade
Bacteria sense virus-induced genome degradation via methylated mononucleotides.
NAD+ (Nicotinamide Adenine Dinucleotide) · Science (New York, N.Y.) · 2026Top journal
Bacteria have developed a defense system called Metis that senses phage-induced genome degradation, potentially halting infection through NAD+ depletion.
Not reported in abstract.
Showing 25 of 41