Research library

C

grade

This genomic study enhances biosecurity preparedness by providing molecular tools for monitoring non-native snail species in Australia.

Genome sizes ranged from 13.7 to 14.3 kb.

summary

D

grade

Berberine shows promise in preclinical MS models, but clinical trials are necessary to confirm its efficacy and safety in humans.

Not reported in abstract.

summary

D

grade

Tannins show promise in reducing protein degradation during ensiling, but further experimental validation is needed to confirm their practical benefits.

Tannin supplementation significantly reduced NH₃-N, NPN, and soluble nitrogen concentrations (p < 0.001).

summary

C

grade

The high-purity mogroside ingredient appears safe in rats, with no genotoxic effects observed at high doses. Human studies are needed for confirmation.

NOAEL of 50,000 ppm in male rats (3309 mg/kg-bw/day) and female rats (3362 mg/kg-bw/day) in 90-day study.

summary

C

grade

Directed evolution of GtAOX_M3 significantly enhances methanol bioconversion efficiency, offering potential industrial applications.

Sixfold increase in catalytic efficiency (7.7 s^-1 mM^-1).

summary

C

grade

Engineered P450 OleP mutants show enhanced catalytic efficiency for synthesizing therapeutic bile acids from lithocholic acid, but further research is needed to assess industrial applicability.

MDCA conversion rate improved from 32.5% to 98.3% with S240A mutant.

summary

C

grade

This study provides a novel approach to understanding the effects of POR mutations on steroid hormone synthesis using engineered human cell models.

Not reported in abstract.

summary

D

grade

This study highlights significant genetic associations between NAD+ precursors and type 2 diabetes across different ancestry groups, particularly noting a strong signal in the European population.

Stouffer Z = −9.70 for fatty-acid-degradation association in the European group, permutation p = 0.0077.

summary

D

grade

Not reported in abstract.

summary

D

grade

Not reported in abstract.

summary

B

grade

This study highlights the variability in 31P-MRS measurements of brain metabolites, emphasizing the need for careful planning in clinical trials to ensure reliable results.

Test-retest variability ranged from ∼5-25 CoV%, n=Not reported in abstract.

summary

C

grade

Aging appears to disrupt the metabolic coupling between oocytes and cumulus cells, which may impair NAD homeostasis and contribute to reproductive challenges.

Not reported in abstract.

summary

C

grade

NAD+ depletion appears to trigger a countdown to birth in mice, but the implications for human pregnancy remain unclear.

summary

D

grade

Mitochondrial quality control is vital for healthy ageing, and strategies like NAD+ may support this process, though specific evidence is not detailed in the review.

summary

C

grade

Bacteria have developed a defense system called Metis that senses phage-induced genome degradation, potentially halting infection through NAD+ depletion.

Not reported in abstract.

summary

C

grade

The study found that IDO1 inhibition combined with radiation increased apoptosis in colon cancer cells while decreasing NAD+ levels, but the clinical implications of these findings are uncertain.

NAD+ levels decreased by additional 1-MT in radiated Colon26 cells (452 vs. 1027 nmol/g, p = 0.0495)

summary

C

grade

Nicotinamide riboside supplementation improved motor performance and dopamine signaling in a mouse model of Parkinson's disease, but did not prevent neuron degeneration.

Not reported in abstract.

summary

A

grade

Nicotinamide riboside injections appear to be well tolerated with some discomfort, but further studies with larger sample sizes are needed to confirm safety and efficacy.

Not reported in abstract.

summary

D

grade

The study suggests that redox cofactor swaps could theoretically enhance growth rates in Acetobacterium woodii, but practical applications and outcomes remain to be validated.

Up to 2.5-fold increase in growth rate under broader concentration ranges.

summary

C

grade

This study indicates that changes in the microbiome may disrupt tryptophan metabolism and contribute to behavioral issues in a mouse model of chronic colitis, but the implications for human health remain unclear.

Not reported in abstract.

summary

B

grade

NAD+ precursor supplementation may reverse NK cell exhaustion and restore antitumor activity in DLBCL, but further human studies are needed to confirm these findings.

Not reported in abstract.

summary

C

grade

Flavonoids from Elsholtzia ciliata inhibited PTP1B with IC50 values below 5.4 µM, showing potential for restoring metabolic balance in vitro, but their clinical relevance remains unproven.

IC50 < 5.4 µM for PTP1B inhibition.

summary

C

grade

The engineered FSA variants showed a 34-fold increase in efficiency and achieved an 88% yield in converting methanol to mannitol, but these findings are limited to in vitro conditions.

34-fold increase in catalytic efficiency compared to wildtype FSA.

summary

B

grade

NMN does not impair human sperm motility at concentrations of 50 µM and 100 µM, but 150 µM may have harmful effects.

Not reported in abstract.

summary

C

grade

LmME2 is crucial for maintaining NAD+ levels and redox balance in Leishmania major, with its deletion leading to increased ROS and reduced virulence in mice.

Not reported in abstract.

summary