Research library

C

grade

The PDMI nanoparticle shows promise in reducing friction and inflammation in a rat model of post-traumatic osteoarthritis, but further research is needed to determine its efficacy in humans.

OARSI score reduced by more than 80% in a 4-week rat PTOA model.

summary

C

grade

Tubuloside A shows potential in reducing sepsis-induced splenic injury in mice by targeting oxidative stress and inflammation, but human studies are needed to confirm its clinical relevance.

TA significantly alleviated splenic injury and improved survival in septic mice.

summary

C

grade

KBG shows potential in improving renal function and mitochondrial homeostasis in DKD models, but human studies are needed for clinical validation.

Not reported in abstract.

summary

C

grade

SWDJ shows promise in reducing hypoxic lung injury in preclinical models, but human studies are needed to assess its clinical potential.

32.5% reduction in lung wet/dry weight.

summary

C

grade

Guizhi Wuling Decoction may alleviate myocardial fibrosis in mice by restoring mitochondrial homeostasis via AMPK/PGC-1α signaling, but human relevance is unproven.

Not reported in abstract.

summary

C

grade

Polydatin may improve mitochondrial function and reduce oxidative stress in MAFLD, but human studies are needed to confirm its therapeutic potential.

Not reported in abstract.

summary

C

grade

MLSTP may reduce muscle swelling in femoral fracture rats by enhancing mitophagy and suppressing ferroptosis, but human relevance is unclear.

Not reported in abstract.

summary

C

grade

MOA shows potential for reducing myocardial injury in rats, but human studies are needed to confirm its clinical relevance.

MOA reduced infarct size and improved cardiac function in vivo.

summary

C

grade

Zhenwu Decoction shows potential in reducing prostate enlargement and modulating oxidative stress and apoptosis in a rat model of BPH, but human studies are needed to confirm its efficacy.

ZWD reduced prostate volume, prostate weight, and prostate index in TP-induced BPH rats.

summary

C

grade

DNJ shows promise in reducing diabetic cardiomyopathy markers in preclinical models, potentially through the PI3K/AKT pathway, but human studies are needed to confirm its therapeutic potential.

Not reported in abstract.

summary

C

grade

HPcLW nanoparticles show potential in targeting osteoarthritis pathways in mice, but human applicability remains to be tested.

Joint fluorescence retention extended to 10 days post-injection.

summary

C

grade

Targeting TLR2 may reduce inflammation and restenosis during the degradation of PLA scaffolds, but further studies are needed to confirm these findings in humans.

Not reported in abstract.

summary

D

grade

Gut-derived metabolites affect mitochondrial function, but current evidence is mostly preclinical and should guide future research rather than immediate clinical practice.

summary

B

grade

Angiogenin appears to be associated with cognitive performance in older adults at risk for dementia, but the clinical significance of this finding remains uncertain.

Angiogenin associated with cognitive performance (β = 0.50, SE = 0.14, P < 0.001, f² = 0.08).

summary

C

grade

R13A-MOTS-c shows potential in reducing radiation-induced lung injury in mice, but its clinical applicability and effectiveness in humans remain to be determined.

Not reported in abstract.

summary

B

grade

Malignant odontogenic tumors are rare, with ameloblastic carcinoma being the most common subtype, found in 58.5% of cases. The majority of these tumors occur in the mandible, with a mean patient age of 41.4 years.

58.5% of cases were ameloblastic carcinoma.

summary

B

grade

Both mini-abdominoplasty and mini-inverted-T abdominoplasty are options for patients with post-gravidic diastasis recti, but the choice may depend on individual concerns regarding scars versus overall abdominal shape.

6.94 ± 1.17 vs 5.51 ± 1.25; P < .001 for scar quality rating

summary

A

grade

The pilot study suggests that closed-incision negative pressure therapy may reduce wound dehiscence rates compared to conventional dressings, but further research is needed to confirm these results.

Wound dehiscence rates were 16.7% in the intervention and 41.7% in the control group.

summary

C

grade

MOTS-c appears to have a protective effect against hyperoxia-induced cardiac injury in neonatal mice, but its relevance to human conditions is not established.

Not reported in abstract.

summary

B

grade

MOTS-c may activate metabolic pathways in MSCs but could also increase senescence and inflammation, potentially impairing their reparative function.

MOTS-c reduced proliferation in obese MSCs, p<0.05.

summary

B

grade

Individuals with cerebral palsy show similar levels of mitochondrial-derived microproteins as typically developing individuals, suggesting preserved signaling despite differences in physical fitness.

Not reported in abstract.

summary

D

grade

Not reported in abstract.

summary

C

grade

MOTS‑c may help reduce placental injury in hypoxia-induced IUGR, but its effectiveness in humans remains to be established.

Not reported in abstract.

summary

B

grade

MOTS-c levels are associated with acute coronary syndrome and may help predict major cardiac events, but the clinical implications require further investigation.

Sensitivity of MOTS-c in predicting unstable angina and acute myocardial infarction was 0.890, cutoff value 326.65 ng/mL, 95% CI 253.41-631.84, p<0.001.

summary