Research library

B

grade

Normal coagulation tests should not delay emergency brain CT in uremic children with acute neurological deterioration.

Not reported in abstract.

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A

grade

The combination of Ginkgo biloba and Desmopressin appears to be more effective for treating nocturnal enuresis in children than either treatment alone.

Median wet nights per week after 3 months: combination group 0 [IQR 0-2], GBE 6 [0.5-6.5], Desmopressin 2 [0-6], p<0.001.

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B

grade

Caregivers find desmopressin easy to manage but challenging to prepare and administer, indicating a need for more user-friendly pediatric formulations.

Not reported in abstract.

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D

grade

This review offers an updated synthesis of Type 2A von Willebrand Disease, focusing on its pathophysiology and management but lacks new experimental insights.

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A

grade

Combining desmopressin with anticholinergic agents may improve treatment outcomes for nocturnal enuresis in children, but further research is needed to confirm these findings.

Desmopressin plus oxybutynin, tolterodine, or solifenacin significantly improved CR compared to desmopressin monotherapy.

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D

grade

This paper provides the first international clinical consensus guidelines for managing Wolfram syndrome, with 35 statements achieving strong agreement among experts.

35 final consensus statements reached ≥80% agreement.

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A

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This study confirms that the new desmopressin acetate oral solution is bioequivalent to the tablet formulation, which may facilitate its regulatory approval.

Geometric mean ratio of 101.9% (93.9%-110.5%) for Cmax.

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B

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This report highlights a rare case of AVP deficiency potentially linked to the 9-valent HPV vaccine, with complete resolution of symptoms following desmopressin treatment.

Not reported in abstract.

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B

grade

Alterations in maximum urinary osmolality in children with ADPKD appear to be limited, suggesting that vasopressin may not significantly influence kidney growth in early life.

Not reported in abstract.

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B

grade

This case highlights the rare occurrence of dual tubular defects in a young patient with primary Sjögren’s syndrome, emphasizing the need for careful diagnostic evaluation in similar presentations.

Urine osmolality remained below 150 mOsm/kg after desmopressin.

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D

grade

Not reported in abstract.

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B

grade

This case highlights the complexities of managing adipsic arginine vasopressin deficiency, particularly after neurosurgery, and the need for careful monitoring and titration of desmopressin.

320 mOsm/kg plasma osmolality.

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B

grade

This case indicates that initiating long-acting growth hormone therapy may lead to diabetic ketoacidosis even in children without prior diabetes, particularly in those with obesity and on glucocorticoids.

Hemoglobin A1c was 5.7% (reference range, <5.7%)

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B

grade

Continuing aspirin therapy before burr-hole drainage for chronic subdural hematoma may increase the risk of early postoperative hemorrhagic events.

6 acute (≤48 h) hemorrhagic events (5.8%) occurred: 4/19 (21.1%) with continuation versus 0/40 (0%) and 2/45 (4.4%) with short and long pause (three-group p = 0.005).

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B

grade

Hypernatremia after subarachnoid hemorrhage should not be automatically attributed to AVP deficiency; hypothalamic adipsia may also be a contributing factor.

Not reported in abstract.

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C

grade

This study identifies Del-1 as a myokine that may link muscle health to bone density in the context of hyponatremia in mice.

Not reported in abstract.

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B

grade

Hives are reported by a significant portion of patients with POTS and NMH, and their frequency is associated with greater symptom burden.

42.6% reported hives sometimes, n=188.

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