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SPARC: a structural pathogenicity algorithm for risk classification of hERG variants.
Cardiogen (AEDR) · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026 · Observational · n=1727
SPARC identifies high-risk hERG variants using a structural pathogenicity score, potentially aiding in the interpretation of genetic testing results.
260 variants identified as high risk of pathogenicity with SPS ≥3.25.