Research library

B

grade

Heterozygous germline mutations in MSH3 and MLH3 are associated with increased colorectal cancer risk, suggesting they may be included in genetic screening for CRC.

2.2-fold increased risk of CRC for heterozygous MSH3 mutations, P=6.6x10^-5

summary

B

grade

The study suggests that mycetoma grains create an immunosuppressive environment, potentially aiding pathogen persistence.

Not reported in abstract.

summary

B

grade

This study highlights that men may have a more robust immune response to TLR9 agonists compared to women, suggesting a need for sex-specific approaches in melanoma immunotherapy.

Not reported in abstract.

summary

B

grade

This study indicates that lactylation-related methylation patterns may help stratify cutaneous melanoma patients into high- and low-risk groups, potentially informing treatment strategies.

Kaplan-Meier log-rank test, p=0.046 for survival differences between clusters.

summary

A

grade

Combining chemotherapy with immunotherapy may improve survival in some patients with microsatellite stable metastatic colorectal cancer, but the benefits may vary based on individual patient characteristics.

Median OS not reached vs 15.3 months; HR=0.58; 95% CI, 0.36-0.96; p=0.03.

summary