Research library

B

grade

Indoor falls in older adults with hip fractures are associated with higher risks of functional dependence and mortality, highlighting the need for careful risk assessment in this population.

Indoor falls were independently associated with higher risks of mortality (adjusted HR 2.27, 95% CI 1.45-3.54, p<0.001).

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B

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Caffeine consumption is common among university students, and its relationship with sleep problems is influenced by depressive symptoms.

CUD had a significant direct effect on sleep problems, p<0.001.

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D

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Polθ is a promising target for cancer therapy due to its overexpression in tumors, but further clinical validation is needed.

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B

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Infectious disease outbreaks exacerbate gendered socioeconomic disparities, with women in Guinea facing greater caregiving burdens and income loss. Tailored interventions are needed to address these intersectional vulnerabilities.

N=906 survey participants aged 18 and over.

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C

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CAF and T-cell interactions may enhance adenosine production, potentially contributing to immune evasion in NSCLC, but clinical implications require further investigation.

Not reported in abstract.

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B

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In this study, off-label underdosing of DOACs in Asian AF patients was common but did not significantly impact stroke or bleeding outcomes. Further research is needed.

20.4% of patients were underdosed.

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D

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Only 18.3% of FIFA Member Associations reported having heading coaching materials, and those that exist often lack sufficient detail for effective use.

13 MAs (18.3%) reported having heading coaching material.

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B

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Nursing students face significant limitations in opportunities to practice essential nursing skills during clinical placements, which may affect their readiness for professional practice.

Not reported in abstract.

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C

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Supplementing weaned piglets' diets with curcumin-loaded nanoparticles may improve growth and metabolic health, but further research is needed to confirm these effects.

Final body weight significantly higher in 30 and 60 mg/kg SL@Cur groups compared to control diet, p<0.05.

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D

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Wastewater surveillance has revealed that rat HEV is present in 70% of cities studied, indicating a broader geographic range than previously known.

70% of cities detected Rocahepevirus ratti (rat HEV) genotype C1.

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B

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Older adults may accept mHealth technologies, but skepticism about data accuracy can limit their engagement and willingness to change behaviors.

Not reported in abstract.

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B

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The study documents the southernmost occurrence of the Light-mantled Albatross in the Weddell Sea, highlighting the importance of monitoring these seabirds in high-latitude marine environments.

Not reported in abstract.

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C

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This study identifies pro-inflammatory endothelial cell subsets associated with plaque instability in atherosclerosis, highlighting the complexity of endothelial cell roles in vascular health.

Not reported in abstract.

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C

grade

BGC1201 is a potent allosteric SHP2 inhibitor showing significant antitumor activity in preclinical models, but its clinical application remains to be established.

IC50 of 2.47 nM for SHP2-WT phosphatase inhibition.

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B

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Public awareness of invasive mosquitoes is high, but actual preventive behaviors are lacking, highlighting the need for targeted education campaigns.

58.6% of respondents met the inclusion criteria, n=1064.

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B

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A specific pattern of fluency performance may help identify recent minor cognitive decline in older adults, even without baseline data.

79.5% accuracy in identifying minor cognitive decline, 95% CI [73.2%, 84.9%]

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C

grade

This study presents a new method for producing selenoproteins in bacteria, achieving enzymatic activities of approximately 420 U/mg for GPx1 and 290 U/mg for its mutant variant.

Enzymatic activity of GPx1 was around 420 U/mg.

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D

grade

Not reported in abstract.

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B

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Not reported in abstract.

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B

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Earlier trauma exposure, especially sexual and emotional abuse, is linked to greater mental health challenges later in life, highlighting the need for trauma-informed care that considers age and type of trauma.

Not reported in abstract.

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B

grade

The study found that an eight-lncRNA risk score is associated with overall survival in glioma, but full validation of the model is needed before any clinical implications can be drawn.

In CGGA325 (n=313), HR = 1.54, 95% CI: 1.37-1.74, P = 4.78 × 10^-13.

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C

grade

ARA 290 improved insulin sensitivity but did not restore cognitive flexibility deficits in db/db mice, indicating that metabolic improvements alone may not address cognitive dysfunction in diabetes.

Not reported in abstract.

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B

grade

Higher fish consumption, especially tilapia, is linked to better Omega-3 and vitamin D levels among adolescent females in Bangladesh, but causality cannot be established.

Mean O3I was 4.3% during dry season and 4.9% in wet season.

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B

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Caffeine consumption is prevalent among university students in Bangladesh, especially among females and those not studying nutrition, with headaches commonly reported as withdrawal symptoms.

34.0% drinking caffeine once daily, n=not reported in abstract.

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B

grade

ECHDC3 knockdown significantly affects mitochondrial function and metabolism in AML, but the clinical implications for chemotherapy resistance require further investigation.

Knockdown of ECHDC3 significantly reduced the mitochondrial membrane potential, p < 0.0001.

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