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Association of Clonal Hematopoiesis With Silent Brain Lesions and Cognitive Decline in Patients With Atrial Fibrillation.
Adamax · Circulation · 2026 · ObservationalHigh-impact journal
In patients with atrial fibrillation, clonal hematopoiesis is associated with a greater burden of silent brain lesions and accelerated cognitive decline over time.
CHIP carriers had higher odds of cerebral microbleeds (OR, 1.45 [95% CI, 1.09 to 1.93]) and WMLs (OR, 1.56 [95% CI, 1.20 to 2.04]) at baseline.