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A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Acmopatide (CT-868), a Fully Biased GLP-1/GIP Receptor Agonist, in Adults With Type 1 Diabetes and Overweight or Obesity.
Acmopatide · Diabetes care · 2026 · RCT · Phase 2High-impact journal
Acmopatide showed statistically significant improvements in HbA1c and weight loss in adults with type 1 diabetes, but the clinical significance of these changes may be limited.
HbA1c least squares mean change from baseline -0.4 to -0.6% vs. -0.3% with placebo, P = 0.020.