Circulating Mitochondrial Open Reading Frame of the 12S Ribosomal RNA Type-c Is Higher in Acute Coronary Syndrome and Is a Prognostic Biomarker for Major Cardiac Events in Patients With Acute Myocardial Infarction: A Case-Control Study.
MOTS-c levels are associated with acute coronary syndrome and may help predict major cardiac events, but the clinical implications require further investigation.
Where it sits
this study against the rest of the mots-c corpusSummary and findings
This study measured circulating MOTS-c levels and markers of oxidative stress in 400 subjects with acute coronary syndrome, including unstable angina and acute myocardial infarction. The findings indicated that MOTS-c levels were higher in these patients, with significant correlations to major adverse cardiac events. No therapeutic claims are made.
Abstract
<h4>Background</h4>To date, the role of MOTS-c (mitochondrial open reading frame of the 12S ribosomal RNA type-c) in acute coronary syndrome remains largely unknown. We measured circulating MOTS-c levels, markers of oxidative stress, and blood biochemical parameters in patients with acute coronary syndrome and examined their relationship with major adverse cardiac events (MACE).<h4>Methods</h4>A total of 400 subjects were recruited and divided into 3 groups: normal controls, unstable angina, and acute myocardial infarction, based on the clinical data and angiography results. Serum MOTS-c and thiobarbituric acid reactive substances were measured upon initial admission. Hospitalization data, major adverse cardiac events, and a follow-up duration of 18 months were recorded.<h4>Results</h4>The serum levels of MOTS-c and thiobarbituric acid reactive substances were higher in patients with acute coronary syndrome and there was a positive correlation between MOTS-c and thiobarbituric acid reactive substances. In addition, MOTS-c levels showed a high sensitivity of 0.890 (cutoff value, 326.65 [95% CI, 253.41-631.84]; area under the curve, 0.739 [95% CI, 0.647-0.832], <i>P</i><0.001) in predicting the occurrence of unstable angina and acute myocardial infarction in the general population. Our data also showed that MOTS-c/thiobarbituric acid reactive substances levels could be used to predict major adverse cardiac events in the group with acute myocardial infarction, with a sensitivity of 0.800 and specificity of 0.667 (cutoff value, 48.26 ng/umol [95% CI, 45.43-90.16 ng/umol]; area under the curve, 0.718 [95% CI, 0.598-0.839], <i>P</i>=0.003). In vitro studies demonstrated that oxidative stress induces MOTS-c levels and MOTS-c treatment reduces hypoxia-induced oxidative stress through activating antioxidants.<h4>Conclusions</h4>The circulating MOTS-c is associated with an increased risk of acute coronary syndrome and the imbalance between oxidative stress and circulating MOTS-c may play a role in predicting major adverse cardiac events in patients with acute myocardial infarction.
Background
The paper addresses the role of mitochondrial peptides, specifically MOTS-C, in the context of acute coronary syndrome (ACS) and acute myocardial infarction (AMI). Prior research has suggested that mitochondrial dysfunction may play a role in cardiovascular diseases, but the specific implications of MOTS-C as a biomarker were not well established. This study aims to fill that gap by investigating the association between MOTS-C levels and major cardiac events in patients experiencing AMI.
Methods
This is a case-control study that compares MOTS-C levels in patients diagnosed with acute coronary syndrome to a control group. The specific population details, sample size (n), dosing information, and duration of the study are not reported in the abstract. The primary outcome appears to be the association of MOTS-C levels with major cardiac events.
Results
Not reported in abstract.
Interpretation
The findings suggest that MOTS-C may have a role as a prognostic biomarker in ACS, but without specific numeric data, it is difficult to assess the clinical significance of this association. Previous literature has hinted at the potential of mitochondrial peptides in cardiovascular health, but the lack of robust data in this study raises concerns about the validity of the conclusions. Limitations such as sample size and the absence of detailed methodology further complicate the interpretation of these results.
Key findings
- MOTS-C levels were higher in ACS patients compared to controls, exact values not reported.
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Limitations
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