The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

The Concise Guide to PHARMACOLOGY 2023/24 is a comprehensive reference for drug targets and their interactions, useful for both researchers and clinicians.

Summary and findings

The Concise Guide to PHARMACOLOGY 2023/24 provides overviews of approximately 1800 drug targets and about 6000 interactions with around 3900 ligands. It emphasizes selective pharmacology and offers a point-in-time record of pharmacological information. The guide is produced in conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology.

Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Key findings

• Approximately 1800 drug targets covered.
• About 6000 interactions with approximately 3900 ligands.
• Material presented is substantially reduced compared to the website.

Limitations

• Not a primary research study.
• No new experimental data reported.
• Focuses on summarization rather than original research findings.

Elsewhere in the ABS-201 corpus