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Study 15 of 19Lixisenatide literatureVeterinary and animal science · Observational2026

Physiological benefits of protected AD3E on nutrient digestibility, hematology, and small intestinal morphology and carcass characteristics in fattening lambs.

Supplementation with rumen-protected AD3E improved weight gain and feed efficiency in fattening lambs, but did not affect nutrient digestibility or intestinal morphology.

Read at Veterinary and animal scienceAdd to compare

Where it sits

this study against the rest of the lixisenatide corpus
1
Preclinical
14
Observational · this one
0
Open-label
2
Randomised
2
Reviews

Summary and findings

The study measured the effects of rumen-protected AD3E supplementation on performance, rumen fermentation, and small intestinal morphology in 24 male fattening lambs over 70 days. Two treatment groups received different levels of vitamin AD3E, resulting in improved daily weight gain and feed conversion ratio compared to a control group. Nutrient digestibility remained unaffected, and no significant changes were observed in small intestinal morphology or carcass traits.

How much of this paper we could read: full text read (0.70). We had a clear abstract, so the summary below closely tracks the paper. What this means →
Final weight of lambs receiving protected vitamin supplement was higher than control group (P < 0.05).2026

Abstract

The authors’ words, as Veterinary and animal science supplied them

Adequate intake of fat-soluble vitamins, including vitamin A, D<sub>3</sub>, and E, is essential for fattening lambs due to their roles in immune competence, metabolic regulation, and antioxidant protection. Conventional diets often provide inconsistent levels of these vitamins, making supplementation necessary. The present study was conducted to investigate the effect of different levels of rumen-protected AD<sub>3</sub>E supplementation on performance, rumen fermentation, feed digestibility, quantitative carcass characteristics, and small intestinal morphology of fattening lambs. Twenty-four male lambs (4-month-old) with a body weight of 34.11 ± 2.2 kg were divided into three groups in a completely randomized design for 70 days. The experimental treatments included a control group fed a basal diet (without vitamin supplementation), a second group fed a basal diet plus 1 kg/t of vitamin AD<sub>3</sub>E, and a third group fed a basal diet plus 2 kg/t of vitamin AD<sub>3</sub>E. Growth performance, nutrient digestibility, rumen fermentation parameters, and carcass traits were evaluated. The results showed that the use of protected AD3E improved the daily weight gain and feed conversion ratio of male lambs in the two vitamin-receiving groups compared to the control group (P < 0.05).The final weight of lambs receiving the protected vitamin supplement was higher than that of the control group (P < 0.05). Digestibility of nutrients remained unaffected. In comparison with the control group, rumen protozoa (total population and Entodinium) significantly increased in lambs that received vitamin at a level of 1 kg per ton (P < 0.05). Blood parameters showed alterations, including reduced glucose at 1 kg/ton, increased total protein and reduced cholesterol at 2 kg/ton, and elevated hematocrit and hemoglobin with supplementation. Small intestinal morphology showed no significant changes in villus height or crypt depth. Carcass traits were unaffected. In general, the results showed that the use of protected vitamin AD<sub>3</sub>E supplement in lamb diets improved the performance of fattening lambs (Final Body Weight (kg), Total Weight Gain (kg) and Daily Weight Gain (g)) through a positive effect on rumen fermentation, although it did not affect diet digestibility.

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