Study 21 of 23NAD+ (Nicotinamide Adenine Dinucleotide) literatureScience (New York, N.Y.)Top journal2026
The placental metabolic clock.
NAD+ depletion appears to trigger a countdown to birth in mice, but the implications for human pregnancy remain unclear.
Where it sits
this study against the rest of the nad+ (nicotinamide adenine dinucleotide) corpus7
Preclinical · this one
14
Observational
0
Open-label
1
Randomised
1
Reviews
Summary and findings
This study investigates the role of NAD+ depletion in the timing of birth in mice. The findings suggest that NAD+ levels may influence the metabolic processes leading to parturition. No therapeutic claims are made regarding the implications of these findings.
How much of this paper we could read: title only (0.30). The feed gave us little more than the title, so our summary is thin. This says nothing about the study's quality — read the source. What this means →
2026
Abstract
The authors’ words, as Science (New York, N.Y.) supplied them
NAD<sup>+</sup> depletion triggers a countdown to birth in mice.
Background
Not reported in abstract.
Methods
Not reported in abstract.
Results
Not reported in abstract.
Interpretation
Not reported in abstract.
Key findings
- Not reported in abstract.
- Not reported in abstract.
- Not reported in abstract.
Limitations
- Not reported in abstract.
- Not reported in abstract.
Elsewhere in the NAD+ (Nicotinamide Adenine Dinucleotide) corpus
BMetabolite-specific Reproducibility of Cerebral <sup>31</sup> P-MRS at 3T: Recommendations for Clinical Researchbiorxiv-preprint · 2026 · Test-retest variability ranged from ∼5-25 CoV%, n=Not reported in abstract.HumanCAging disrupts cumulus-oocyte NAD homeostasisbiorxiv-preprint · 2023 · n=30 · Not reported in abstract.mixedDMitochondrial quality control in human ageing and longevity.Nature metabolism · 2026—DBacteria sense virus-induced genome degradation via methylated mononucleotides.Science (New York, N.Y.) · 2026 · Not reported in abstract.—CMechanisms of apoptosis in colon cancer cells induced by IDO1 inhibitor and irradiation: A metabolomic studybiorxiv-preprint · 2026 · NAD+ levels decreased by additional 1-MT in radiated Colon26 cells (452 vs. 1027 nmol/g, p = 0.0495)AnimalCNicotinamide Riboside Enhances Mitochondrial Bioenergetics and Dopaminergic Signaling Independent of Neuron Survival in a Double-Hit Parkinson’s Modelbiorxiv-preprint · 2026 · n=20 · Not reported in abstract.Animal