Melanotan 1

Research-centric overview

Peptide

### Melanotan 1 Summary Melanotan 1, also known as afamelanotide, is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) that primarily acts as a melanocortin receptor agonist. It has been investigated for its potential applications in enhancing skin pigmentation and its role in various therapeutic contexts, including neuroprotection and cancer research.

Community effect ratings, structured research logs, and side-effect patterns — all fed by one anonymous form.

Effect profile (overview)

Aggregate AI baseline blended with community voting. Hover to inspect effect strengths per category.

Effect scores blend an AI baseline with community ratings. Open the full chart for per-category detail; rate via the Contribute button.

Research log summary heatmap

Compact view of how logs describe shifts in pain, sleep, and performance (−5 to +5). Treat this as qualitative, anonymous signal only.

No community research logs yet. When structured logs are added, this panel will summarize typical shifts in pain, sleep, and performance.

Anonymous side-effect patterns

Rough heatmap of anonymous side-effect and positive-signal tags — a "most-mentioned" snapshot, not safety or efficacy advice.

No anonymous side-effect reports yet. When reports are submitted, this panel will show a simple heatmap of tags like "nausea", "flushing", "improved healing", and more.

Research footprint

Last analyzed Jul 17, 2026

Studies indexed

Human

Animal

AI analyzed

Evidence mix0% human · 50% animal · 25% cellular · 0% review

Highest phase: PreclinicalYears covered: 2023

Librarian pulse — latest actionsFull changelog ↓

Jul 16, 3:59 PMRe-scoredSeeded effect profile for Melanotan 1
Jul 16, 6:00 AMRefreshedRefreshed content for Melanotan 1
Jul 15, 6:00 AMRefreshedRefreshed content for Melanotan 1

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

Semantic Scholar search for Melanotan 1StudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Polysorbate 80 coated chitosan nanoparticles for delivery of α-melanocyte stimulating hormone analog (NDP-MSH) to the brain reverse cognitive impairment related to neuroinflammation produced by a high-fat diet (HFD).StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression.StudyPubMedPublished Jan 1, 2023Added Dec 12, 2025

Bremelanotide treatment led to a 30% reduction in glioblastoma cell viability and a significant decrease in Survivin expression, but the clinical implications of these findings are not established.

External databases

Helpful external resources for additional structural, pharmacologic, and literature context. These are third-party databases; always cross-check details with primary research.

Practical guides for Melanotan 1

How-to and safety articles applicable to every peptide in the library.

Community notes

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Community research logs (detail)

No community research logs yet. Use the “Contribute data” button above to share an anonymized summary of your experience.

Anonymous side-effect reporting (detail)

This section describes how anonymous side-effect reports are aggregated into the heatmap above. Reports are anonymous and unverified, and should be read alongside primary safety data.

Use the "Report side effects" button to open a focused popup form. Please keep descriptions neutral and avoid medical language; think in terms of "nausea", "flushing", "vivid dreams", etc.

Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

1d agoScoringbackfill70%

Seeded effect profile for Melanotan 1

1d agoRefreshai-researcher85%