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Melanotan 1

Research-centric overview

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### Melanotan 1 Summary Melanotan 1, also known as afamelanotide, is a synthetic analog of α-melanocyte-stimulating hormone (α-MSH) that primarily acts as a melanocortin receptor agonist. It has been investigated for its potential applications in enhancing skin pigmentation and its role in various therapeutic contexts, including neuroprotection and cancer research.

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Research log summary heatmap

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Anonymous side-effect patterns

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Research footprint

Last analyzed Jun 2, 2026
4
Studies indexed
0
Human
2
Animal
4
AI analyzed
Evidence mix0% human · 50% animal · 25% cellular · 0% review
Highest phase: PreclinicalYears covered: 2023
Librarian pulse — latest actionsFull changelog ↓
  • Jun 2, 6:00 AMRefreshedRefreshed content for Melanotan 1
  • May 28, 6:01 AMRefreshedRefreshed content for Melanotan 1
  • May 27, 6:08 AMRefreshedRefreshed content for Melanotan 1

Research & intelligence feed

Studies, clinical trials, community discussions, and news.

Semantic Scholar search for Melanotan 1StudySemanticScholarAdded Dec 12, 2025

Not reported in abstract.

Polysorbate 80 coated chitosan nanoparticles for delivery of α-melanocyte stimulating hormone analog (NDP-MSH) to the brain reverse cognitive impairment related to neuroinflammation produced by a high-fat diet (HFD).StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells.StudyPubMedAdded Dec 12, 2025

Not reported in abstract.

Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression.StudyPubMedPublished Jan 1, 2023Added Dec 12, 2025

Bremelanotide treatment led to a 30% reduction in glioblastoma cell viability and a significant decrease in Survivin expression, but the clinical implications of these findings are not established.

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Community research logs (detail)

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Anonymous side-effect reporting (detail)

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Librarian Changelog

Every time the Librarian touches this peptide — discovering, refreshing, scoring, or verifying — it logs the action here.

11h agoRefreshai-researcher85%

Refreshed content for Melanotan 1

5d agoRefreshai-researcher85%

Refreshed content for Melanotan 1

6d agoRefreshai-researcher85%

Refreshed content for Melanotan 1

May 26task_runlibrarian-runner

Completed task: Refresh content for Melanotan 1

May 26Refreshdiscovery50%

Refreshed content for Melanotan 1

May 26SummarySemanticScholar0%

Auto-summarized study: "Semantic Scholar search for Melanotan 1..."