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HGH (Somatropin) record · updated 13h ago

Muscle & body compMetabolic & appetiteGrade A · human clinicalResearch use only
All 39 studiesJump to the evidenceCompare
What is HGH (Somatropin) used for?

HGH (somatropin) is recombinant human growth hormone, FDA-approved for pediatric and adult GH deficiency and several wasting and short-stature conditions; widely studied for body composition off-label.

How it works: Growth hormone receptor agonist

Primarily researched for · Muscle & body compRoute · Subcutaneous injection

Development stage

where HGH (Somatropin) sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 72 registered trials. It describes the research record, not a recommendation.

Identity
NameHGH (Somatropin)
Chain length—
Molecular weight285.3 Da
FormulaC13H11N5O3
Structure typeSmall molecule
ClassMuscle
Research levelFDA Approved
Discovered byCurated master list · 2026

Mass and formula from PubChem CID 137552069. No verified residue count for this compound.

Pharmacology
MechanismGrowth hormone receptor agonist
RouteSubcutaneous injection
Half-life~20 min
Time to peak3–6 hours
DurationVariable
Extraction confidence0.90
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Aug 22, 2026. How this works →
Research stats
Total studies39
Human / animal / cellular30 / 2 / 0
Highest trial phasePhase 4
Years covered2020–2026
Latest study20h ago
Publication history
20202026
Research funding
209 NIH projects · $22.8M awarded · through FY2025
Public grants naming this compound. Funding is interest, not evidence.
Safety signals
FAERS reports6
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

39 rows · newest 12 shownOpen in the library →
StudyTypeYearSummary depth
Real-World Adult Height Outcomes in Girls with Central Precocious Puberty Receiving GnRHa Monotherapy or Combined with Growth Hormone: A Cohort Study in China.
FindingGnRHa + rhGH group AHG: 1.72 SDS (1.24, 2.59).
Human2026Full text read0.80
[Prospects and mechanistic insights into the use of recombinant human growth hormone in the treatment of pediatric inflammatory bowel disease].
TakeawayRecombinant human growth hormone (rhGH) may offer a new avenue for managing growth retardation in pediatric inflammatory bowel disease, but more research is needed to confirm its efficacy and safety.
review2026Full text read0.70
GH-IGF-1 axis and rhGH outcomes in children with GHD, ISS and SGA: a systematic review and meta-analysis.
FindingBaseline IGF-1 SDS was lowest in GHD (-2.9 ± 1.1) compared with ISS (-1.5 ± 1.2) and SGA (-1.3 ± 1.1; p<0.001).
review2026Full text read0.90
Comparative Effects of Local Denosumab and Recombinant Human Growth Hormone on Periodontal Remodeling in Experimental Periodontitis.
FindingFacial bone height: 11.97 ± 0.05 mm for DNS vs. 9.96 ± 0.06 mm for rhGH, P = 0.004.
Animal2026Full text read0.80
Precision medicine in pediatric growth disorders: Integrating clinical phenotype, genetics, IGF-1 biology and artificial intelligence: A systematic scoping review of PubMed-indexed literature (2000-2026).
FindingIGF-1/IGFBP-3 M ratio sensitivity 87.5%, specificity 83.0% for GH deficiency.
review2026Full text read0.80
Building the adult growth hormone deficiency data mart: a Real-World model of AI-driven clinical data extraction in a single Italian center.
Finding188 validated AGHD patients out of 210 identified.
Human2026Full text read0.80
Discovery and optimization of a pH-responsive ultra-long-acting VHH-based growth hormone mimetic.
Finding227-fold difference in dissociation rates between neutral and acidic conditions.
Animal2026Full text read0.80
Associations of endocrine disrupting chemicals with anogenital distance across infancy.
FindingEach quartile increase in the phthalate/replacement mixture was associated with -4.13 mm/m shorter AGIShort (95% CI: -7.22, -1.05) in 5-month-old females.
Human2026Full text read0.80
Metabolic and muscular effects of switching from somatropin to somapacitan in adults with growth hormone deficiency.
Findingmean difference -0.2 kg in total lean mass change at week 52, 95% CI -1.5 to 1.1
Human2026Full text read0.80
Metabolic and muscular effects of switching from somatropin to somapacitan in adults with growth hormone deficiency.
Findingmean difference -0.2 kg in total lean mass change at week 52, 95% CI -1.5 to 1.1
Human2023Full text read0.80
Pharmacogenetic hypersensitivity to somatropin in a child with severe growth hormone deficiency and <i>MC4R</i> p.V166I variant.
FindingIGF-1 levels increased from -3.35 SDS to +8.00 SDS.
Human2026Full text read0.80
Comparative Efficacy and Safety of Jintrolong and Other Long-Acting Growth Hormones for Growth Hormone Deficiency in East Asia: A Systematic Review and Network Meta-Analysis.
FindingJintrolong HV: MD 0.86 cm/year; 95% CI, 0.13 to 1.6.
review2026Full text read0.80

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching HGH (Somatropin) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much HGH (Somatropin) is discussed should be drawn from it.