Peptides DB
Research-centric peptide and protocol reference hub

FGL (FG Loop Peptide) record · updated 18h ago

Neuro & moodHealing & recoveryGrade B · human evidenceResearch use only
All 11 studiesJump to the evidenceCompare
What is FGL (FG Loop Peptide) used for?

FGL is a synthetic 15-amino-acid peptide derived from the NCAM FG loop, studied preclinically as an FGFR agonist for synaptic plasticity, memory, and neuroprotection.

How it works: FGFR agonist

Primarily researched for · Neuro & mood

Development stage

where FGL (FG Loop Peptide) sits between preclinical work and regulatory approval
  1. 1Current
    Preclinical
    Animal / in-vitro work
  2. 2Not reached
    Phase 1
    Safety in humans
  3. 3Not reached
    Phase 2
    Efficacy signal
  4. 4Not reached
    Phase 3
    Confirmatory trials
  5. 5Not reached
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 33 registered trials. It describes the research record, not a recommendation.

Identity
NameFGL (FG Loop Peptide)
Chain length—
Molecular weight—
Formula—
Structure type—
ClassNeuro
Research levelPreclinical
Discovered byCurated master list · 2026
Pharmacology
MechanismFGFR agonist
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.70
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Oct 9, 2026. How this works →
Research stats
Total studies11
Human / animal / cellular4 / 3 / 1
Highest trial phasePreclinical
Years covered2022–2026
Latest study8d ago
Publication history
20222026
Research funding
—no NIH grants found
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

11 rowsOpen in the library →
StudyTypeYearSummary depth
Diet-induced Fasting Ghrelin Elevation Reflects the Recovery of Insulin Sensitivity and Visceral Adiposity Regression.
FindingFGL increased by 10.5% in the green-MED group, P = 0.03 for green-MED vs HDG.
Human2022Full text read0.80
Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer.
TakeawayNot reported in abstract.
—2024Title only0.10
Abatacept versus hydroxychloroquine for prevention of rheumatoid arthritis in individuals with palindromic rheumatism: a randomized open-label trial.
TakeawayNot reported in abstract.
Human2026Title only0.10
Fgl-1 promotes the progression of endometrial adenocarcinoma through PI3K/AKT signal pathway.
Finding60% reduction in Fgl-1 expression after lentiviral silencing.
In vitro2026Full text read0.70
Physicochemical and sensory properties of croissant snack made from wheat-grasshopper flour.
FindingEssential amino acids increased to 32.46 g/100 g in enriched croissants compared to 30.8 g/100 g in control samples.
—2023Full text read0.70
From blueprint to build: Metal ions in peripheral nerve development and engineering regeneration.
FindingNot reported in abstract.
review2026Full text read0.70
Comprehensive analysis of mRNA-microRNA-lncRNA expression profiles in post-traumatic elbow heterotopic ossification using RNA sequencing and experimental validation.
FindingIdentified 2,138 DEGs, 40 DEMs, and 905 DELs.
Animal2025Full text read0.80
Distinct T and innate-like lymphocyte reprogramming following lyophilized fecal microbiota transplantation in recurrent <i>C. difficile</i> infection.
FindingNot reported in abstract.
Human2026Full text read0.70
T cell populations are negatively correlated with natural killer and macrophage cell populations in aspirate samples of peripheral lymphadenopathies.
FindingNot reported in abstract.
Human2026Full text read0.80
Single-cell RNA sequencing analysis of bone cancer pain model induced by Lewis lung cancer cells in male mice.
FindingMicroglia increased by 45% and oligodendrocytes increased by 43%.
Animal2026Full text read0.70
Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection.
FindingNot reported in abstract.
Animal2025Full text read0.70

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching FGL (FG Loop Peptide) will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much FGL (FG Loop Peptide) is discussed should be drawn from it.