Peptides DB
Research-centric peptide and protocol reference hub

Dihexa record · updated 17h ago

Neuro & moodHealing & recoveryGrade A · human clinicalResearch use only
All 12 studiesJump to the evidenceCompare
What is Dihexa used for?

Experimental nootropic peptide investigated for neuroprotection, memory, and stroke/spinal-cord recovery.

How it works: PI3K/AKT signaling pathway activation

Primarily researched for · Neuro & mood

Development stage

where Dihexa sits between preclinical work and regulatory approval
  1. 1Cleared
    Preclinical
    Animal / in-vitro work
  2. 2Cleared
    Phase 1
    Safety in humans
  3. 3Cleared
    Phase 2
    Efficacy signal
  4. 4Cleared
    Phase 3
    Confirmatory trials
  5. 5Current
    Approved
    Cleared by a regulator

Stage is inferred from the highest trial phase in the indexed corpus and 7 registered trials. It describes the research record, not a recommendation.

Identity
NameDihexa
Chain length—
Molecular weight504.7 Da
FormulaC27H44N4O5
Structure typeNot established
ClassNeuro
Research levelPreclinical
Discovered byAdded before provenance tracking · 2025

Mass and formula from PubChem CID 129010512. No verified residue count for this compound.

Pharmacology
MechanismPI3K/AKT signaling pathway activation
Route—
Half-life—
Time to peak—
Duration—
Extraction confidence0.60
Effect profile · 0–5
These seven scores are generated by the Librarian — an autonomous agent running GPT-4o over the indexed studies, trials and label data for this compound. No human assigns them and no community vote moves them. Last recomputed Aug 6, 2026. How this works →
Research stats
Total studies12
Human / animal / cellular3 / 5 / 2
Highest trial phasePhase 4
Years covered2010–2026
Latest study28d ago
Publication history
20102026
Research funding
—no NIH grants found
Safety signals
FAERS reportsnone recorded
Serious AEs in animal work—
Community reports—
Positive —Neutral —Negative —
Records

Study register

12 rowsOpen in the library →
StudyTypeYearSummary depth
Effects of a slowly fermentable fiber mixture against the background of a high-protein diet on insulin sensitivity and metabolic health in individuals with overweight: a randomized, placebo-controlled trial.
FindingWhole-body insulin sensitivity significantly decreased, p=0.034.
Human2025Full text read0.80
Placental transport dysfunction in omega-3 and omega-6 fatty acid in patients with gestational diabetes mellitus.
Findingplacenta/mother ratio of cis-11,14,17-eicosatrienoic acid (GDM vs normal: 0.648 vs 0.484, p=0.001)
Human2026Full text read0.80
Calorie-restricted oat diet is associated with zonulin and short-chain fatty acid response in metabolic syndrome: a randomized controlled trial.
FindingSerum zonulin decreased upon 2-d calorie-restricted oat diet compared to baseline, n=27.
Human2026Full text read0.80
Intestinal epithelial Syndecan-1 maintains mucosal homeostasis in inflammatory bowel disease by enhancing <i>Faecalibacterium prausnitzii</i> biofilm formation.
FindingNot reported in abstract.
Animal2026Full text read0.70
Leverage of quick-soluble gelatin microparticles in transarterial chemoembolization of canine urothelial carcinomas.
FindingMedian tumor volume reduction of 76.41% (95% CI: 65.06-78.41%, p<0.001).
Animal2026Full text read0.80
The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories.
Finding34 distinct molecules identified.
review2025Full text read0.70
Striatal cell-type-specific molecular signatures reveal potential therapeutic targets in a model of dystonia.
FindingNot reported in abstract.
Animal2025Full text read0.70
​Temporal proteomic profiling of iPSC-derived human liver organoids reveals optimal maturation for drug metabolism and toxicology.
FindingNot reported in abstract.
In vitro2026Full text read0.70
Semantic Scholar search for Dihexa
TakeawayNot reported in abstract.
—2010Title only0.00
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.
FindingNot reported in abstract.
Animal2021Partial text0.50
Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.
FindingNot reported in abstract.
In vitro2022Partial text0.40
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.
FindingNot reported in abstract.
Animal2023Full text read0.70

What people are saying

anecdotal · not evidence

Unverified first-hand accounts from public forums. These are not studies: nobody checked what was taken, whether it was what the label said, or what else was going on. They count for nothing in the evidence grade above and are shown because a reader searching Dihexa will meet them anyway, and meeting them next to a graded evidence base is better than meeting them alone.

Community collection has not run yet, so this is an empty shelf rather than a quiet one — nothing has been read, and no conclusion about how much Dihexa is discussed should be drawn from it.